Article

GSK-126 protects CA1 neurons from H3K27me3-mediated apoptosis in cerebral ischemia

2021-08-30

Abstract excerpt

<title>Abstract</title> <p>Epigenetics, including histone modifications, play a significant role in central nervous system diseases, but the underlying mechanism remains to be elucidated. The aim of this study was to evaluate the role of H3K27me3 in regulating transcriptomic and pathogenic mechanisms following global ischemic stroke. Here, we found that in vivo ischemic/reperfusion (I/R) injury induced marked upr...

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Literature Corpus work: 194292f3-c082-514e-b288-854abfc61471
DOI: 10.21203/rs.3.rs-849800/v1

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