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Article

Downstream regulatory element antagonist modulator regulates Ca2+ homeostasis and viability in cerebellar neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Nov 2005

Gomez-Villafuertes Rosa, Torres Begoña, Barrio Jorge, Savignac Magali, Gabellini Nadia, Rizzato Federico, Pintado Belen, Gutierrez-Adan Alfonso, Mellström Britt, Carafoli Ernesto, Naranjo Jose R

Abstract excerpt

The Na+/Ca2+ exchangers NCX1, NCX2, and NCX3 are vital for the control of cellular Ca2+ homeostasis. Here, we show that a doublet of downstream regulatory element sites in the promoter of the NCX3 gene mediates transcriptional repression of NCX3 by the Ca2+-modulated transcriptional repressor downstream regulatory element antagonist modulator (DREAM). Overexpression of a DREAM EF-hand mutant insensitive to Ca2+...

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Identifiers

PMID: 16306395
DOI: 10.1523/JNEUROSCI.3912-05.2005
PMCID: PMC6725879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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