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Article

TEC family kinases in health and disease--loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK.

The FEBS journal - 1 Jun 2011

Hussain Alamdar, Yu Liang, Faryal Rani, Mohammad Dara K, Mohamed Abdalla J, Smith C I Edvard

Abstract excerpt

The TEC family is ancient and constitutes the second largest family of cytoplasmic tyrosine kinases. In 1993, loss-of-function mutations in the BTK gene were reported as the cause of X-linked agammaglobulinemia. Of all the existing 90 tyrosine kinases in humans, Bruton's tyrosine kinase (BTK) is the kinase for which most mutations have been identified. These experiments of nature collectively provide a form of...

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Source

Identifiers

PMID: 21518255
DOI: 10.1111/j.1742-4658.2011.08134.x

Genes

BTK
ITK
SYK
TEC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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