Article
Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution.
Human molecular genetics - 15 Dec 2019
Wu Ying, Broadaway K Alaine, Raulerson Chelsea K, Scott Laura J, Pan Calvin, Ko Arthur, He Aiqing, Tilford Charles, Fuchsberger Christian, Locke Adam E, Stringham Heather M, Jackson Anne U, Narisu Narisu, Kuusisto Johanna, Pajukanta Päivi, Collins Francis S, Boehnke Michael, Laakso Markku, Lusis Aldons J, Civelek Mete, Mohlke Karen L
Abstract excerpt
Integration of genome-wide association study (GWAS) signals with expression quantitative trait loci (eQTL) studies enables identification of candidate genes. However, evaluating whether nearby signals may share causal variants, termed colocalization, is affected by the presence of allelic heterogeneity, different variants at the same locus impacting the same phenotype. We previously identified eQTL in...
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