Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organs.

PLoS genetics - 1 May 2018

Huang August Yue, Yang Xiaoxu, Wang Sheng, Zheng Xianing, Wu Qixi, Ye Adam Yongxin, Wei Liping

Abstract excerpt

Postzygotic single-nucleotide mosaicisms (pSNMs) have been extensively studied in tumors and are known to play critical roles in tumorigenesis. However, the patterns and origin of pSNMs in normal organs of healthy humans remain largely unknown. Using whole-genome sequencing and ultra-deep amplicon re-sequencing, we identified and validated 164 pSNMs from 27 postmortem organ samples obtained from five healthy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic Development
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mosaicism

Share to Organ Specificity

Share to Postmortem Changes

Share to Whole Genome Sequencing

Share to Young Adult

Share to Zygote

Source

Open in PubMed Open full text

Identifiers

PMID: 29763432
DOI: 10.1371/journal.pgen.1007395
PMCID: PMC5969758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organs.PMID 29763432Read ↗

Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organsSemantic proximity Read ↗

Analysis of low-level somatic mosaicism reveals stage and tissue-specific mutational features in human development.Semantic proximity Read ↗

Multi-organ analysis of low-level somatic mosaicism reveals stage- and tissue-specific mutational features in human developmentSemantic proximity Read ↗

Patterns of mosaicism for sequence and copy-number variants discovered through clinical deep sequencing of disease-related genes in one million individuals.Semantic proximity Read ↗

Landmarks of human embryonic development inscribed in somatic mutations.Semantic proximity Read ↗

Postzygotic mutations and where to find them - Recent advances and future implications in the field of non-neoplastic somatic mosaicism.Semantic proximity Read ↗

Characterization of early postzygotic somatic mutations through multi-organ analysis.Semantic proximity Read ↗

The rate and spectrum of mosaic mutations during embryogenesis revealed by RNA sequencing of 49 tissuesSemantic proximity Read ↗

Prenatal Life is the Predominant Source of Somatic Mosaicism Across Tissues and AgingSemantic proximity Read ↗

Common postzygotic mutational signature in multiple healthy adult tissues related to embryonic hypoxiaSemantic proximity Read ↗

Human embryonic genetic mosaicism and its effects on development and disease.Semantic proximity Read ↗

Cancer-Causative Mutations Occurring in Early Embryogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.