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Article

Hsp70 Reduces α-Synuclein Aggregation and Toxicity

1 Jun 2004

Abstract excerpt

Aggregation and cytotoxicity of misfolded alpha-synuclein is postulated to be crucial in the disease process of neurodegenerative disorders such as Parkinson's disease and DLB (dementia with Lewy bodies). In this study, we detected misfolded and aggregated alpha-synuclein in a Triton X-100 insoluble fraction as well as a high molecular weight product by gel electrophoresis of temporal neocortex from DLB patients...

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PMID: 15044495
DOI: 10.1074/jbc.m400255200

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