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Article

First genome-wide association study of non-severe malaria in two birth cohorts in Benin.

Human genetics - 1 Dec 2019

Milet Jacqueline, Boland Anne, Luisi Pierre, Sabbagh Audrey, Sadissou Ibrahim, Sonon Paulin, Domingo Nadia, Palstra Friso, Gineau Laure, Courtin David, Massougbodji Achille, Garcia André, Deleuze Jean-François, Perdry Hervé

Abstract excerpt

Recent research efforts to identify genes involved in malaria susceptibility using genome-wide approaches have focused on severe malaria. Here, we present the first GWAS on non-severe malaria designed to identify genetic variants involved in innate immunity or innate resistance mechanisms. Our study was performed on two cohorts of infants from southern Benin (525 and 250 individuals used as discovery and...

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PMID: 31667592
DOI: 10.1007/s00439-019-02079-5

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