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Article

Evidence for additive and interaction effects of host genotype and infection in malaria.

Proceedings of the National Academy of Sciences of the United States of America - 16 Oct 2012

Idaghdour Youssef, Quinlan Jacklyn, Goulet Jean-Philippe, Berghout Joanne, Gbeha Elias, Bruat Vanessa, de Malliard Thibault, Grenier Jean-Christophe, Gomez Selma, Gros Philippe, Rahimy Mohamed Chérif, Sanni Ambaliou, Awadalla Philip

Abstract excerpt

The host mechanisms responsible for protection against malaria remain poorly understood, with only a few protective genetic effects mapped in humans. Here, we characterize a host-specific genome-wide signature in whole-blood transcriptomes of Plasmodium falciparum-infected West African children and report a demonstration of genotype-by-infection interactions in vivo. Several associations involve transcripts...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22949651
DOI: 10.1073/pnas.1204945109
PMCID: PMC3479498

Genes

RAD21
RETN
SCO1
TAPBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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