Article
Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters.
PLoS biology - 1 Oct 2019
Savocco Jérôme, Nootens Sylvain, Afokpa Wilhelmine, Bausart Mathilde, Chen Xiaoqian, Villers Jennifer, Renard Henri-François, Prévost Martine, Wattiez Ruddy, Morsomme Pierre
Abstract excerpt
Endocytosis of membrane proteins in yeast requires α-arrestin-mediated ubiquitylation by the ubiquitin ligase Rsp5. Yet, the diversity of α-arrestin targets studied is restricted to a small subset of plasma membrane (PM) proteins. Here, we performed quantitative proteomics to identify new targets of 12 α-arrestins and gained insight into the diversity of pathways affected by α-arrestins, including the cell wall...
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