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Article

Substrate-induced ubiquitylation and endocytosis of yeast amino acid permeases.

Molecular and cellular biology - 1 Dec 2014

Ghaddar Kassem, Merhi Ahmad, Saliba Elie, Krammer Eva-Maria, Prévost Martine, André Bruno

Abstract excerpt

Many plasma membrane transporters are downregulated by ubiquitylation, endocytosis, and delivery to the lysosome in response to various stimuli. We report here that two amino acid transporters of Saccharomyces cerevisiae, the general amino acid permease (Gap1) and the arginine-specific permease (Can1), undergo ubiquitin-dependent downregulation in response to their substrates and that this downregulation is not...

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Identifiers

PMID: 25266656
DOI: 10.1128/MCB.00699-14
PMCID: PMC4248734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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