Article
The C. elegans P4-ATPase TAT-1 regulates lysosome biogenesis and endocytosis.
Traffic (Copenhagen, Denmark) - 1 Jan 2009
Ruaud Anne-Françoise, Nilsson Lars, Richard Fabrice, Larsen Morten Krog, Bessereau Jean-Louis, Tuck Simon
Abstract excerpt
P-type adenosine triphosphatases (ATPases) of the Drs2p family (P4-ATPases) are multipass transmembrane proteins required to generate and maintain phospholipid asymmetry in membrane bilayers. In Saccharomyces cerevisiae, several members of this family control distinct transport events within the endosomal and secretory pathways. Comparatively, little is known about the functions of P4-ATPases in multicellular...
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