Article
Substrate- and ubiquitin-dependent trafficking of the yeast siderophore transporter Sit1.
Traffic (Copenhagen, Denmark) - 1 Aug 2008
Erpapazoglou Zoi, Froissard Marine, Nondier Isabelle, Lesuisse Emmanuel, Haguenauer-Tsapis Rosine, Belgareh-Touzé Naïma
Abstract excerpt
Eukaryotic plasma membrane transporters are subjected to a tightly regulated intracellular trafficking. The yeast siderophore iron transporter1 (Sit1) displays substrate-regulated trafficking. It is targeted to the plasma membrane or to a vacuolar degradative pathway when synthesized in the presence or absence of external substrate, respectively. Sorting of Sit1 to the vacuolar pathway is dependent on the...
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