Article

Efficient implementation of penalized regression for genetic risk prediction

2018-08-29

Abstract excerpt

Polygenic Risk Scores (PRS) consist in combining the information across many single-nucleotide polymorphisms (SNPs) in a score reflecting the genetic risk of developing a disease. PRS might have a major impact on public health, possibly allowing for screening campaigns to identify high-genetic risk individuals for a given disease. The “Clumping+Thresholding” (C+T) approach is the most common method to derive PRS....

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Literature Corpus work: 03fc8a73-2cd4-50ec-bd9f-b7301477aa34
DOI: 10.1101/403337

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