Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CtIP-mediated resection is essential for viability and can operate independently of BRCA1.

The Journal of experimental medicine - 2 Jun 2014

Polato Federica, Callen Elsa, Wong Nancy, Faryabi Robert, Bunting Samuel, Chen Hua-Tang, Kozak Marina, Kruhlak Michael J, Reczek Colleen R, Lee Wen-Hwa, Ludwig Thomas, Baer Richard, Feigenbaum Lionel, Jackson Stephen, Nussenzweig André

Abstract excerpt

Homologous recombination (HR) is initiated by DNA end resection, a process in which stretches of single-strand DNA (ssDNA) are generated and used for homology search. Factors implicated in resection include nucleases MRE11, EXO1, and DNA2, which process DNA ends into 3' ssDNA overhangs; helicases such as BLM, which unwind DNA; and other proteins such as BRCA1 and CtIP whose functions remain unclear. CDK-mediated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal Proteins, Non-Histone
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Homologous Recombination

Share to Microscopy, Confocal

Share to Poly(ADP-ribose) Polymerase Inhibitors

Share to Poly(ADP-ribose) Polymerases

Share to Tumor Suppressor p53-Binding Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 24842372
DOI: 10.1084/jem.20131939
PMCID: PMC4042650

Genes

BRCA1
EXO1
BLM
DNA2
MRE11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CtIP-mediated resection is essential for viability and can operate independently of BRCA1.PMID 24842372Read ↗

DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice.Semantic proximity Read ↗

Human CtIP mediates cell cycle control of DNA end resection and double strand break repair.Semantic proximity Read ↗

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.Semantic proximity Read ↗

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break RepairSemantic proximity Read ↗

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaksSemantic proximity Read ↗

Human CtIP: A ‘double agent’ in DNA repair and tumorigenesisSemantic proximity Read ↗

The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.Semantic proximity Read ↗

Controlling DNA-end resection: a new task for CDKsSemantic proximity Read ↗

The DNA resection protein CtIP promotes mammary tumorigenesis.Semantic proximity Read ↗

CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiationSemantic proximity Read ↗

CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1Semantic proximity Read ↗

Dbf4-dependent kinase promotes cell cycle controlled resection of DNA double-strand breaks and repair by homologous recombinationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.