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Article

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

Cell - 6 Jun 2013

Callen Elsa, Di Virgilio Michela, Kruhlak Michael J, Nieto-Soler Maria, Wong Nancy, Chen Hua-Tang, Faryabi Robert B, Polato Federica, Santos Margarida, Starnes Linda M, Wesemann Duane R, Lee Ji-Eun, Tubbs Anthony, Sleckman Barry P, Daniel Jeremy A, Ge Kai, Alt Frederick W, Fernandez-Capetillo Oscar, Nussenzweig Michel C, Nussenzweig André

Abstract excerpt

The DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive resection in G1, and thereby favors repair by nonhomologous end-joining (NHEJ) as opposed to homologous recombination (HR). During S phase, BRCA1 antagonizes 53BP1 to promote HR. The pro-NHEJ and antirecombinase functions of 53BP1 are mediated in part by RIF1, the only known factor that requires 53BP1 phosphorylation for its recruitment...

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Share to Chromosomal Proteins, Non-Histone
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Tumor Suppressor p53-Binding Protein 1

Source

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Identifiers

PMID: 23727112
DOI: 10.1016/j.cell.2013.05.023
PMCID: PMC3713552

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.PMID 23727112Read ↗

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