Article
BRCA1 Mutational Complementation Induces Synthetic Viability.
Molecular cell - 4 Jun 2020
Nacson Joseph, Di Marcantonio Daniela, Wang Yifan, Bernhardy Andrea J, Clausen Emma, Hua Xiang, Cai Kathy Q, Martinez Esteban, Feng Wanjuan, Callén Elsa, Wu Wei, Gupta Gaorav P, Testa Joseph R, Nussenzweig André, Sykes Stephen M, Johnson Neil
Abstract excerpt
BRCA1 promotes the DNA end resection and RAD51 loading steps of homologous recombination (HR). Whether these functions can be uncoupled, and whether mutant proteins retaining partial activity can complement one another, is unclear and could affect the severity of BRCA1-associated Fanconi anemia (FA). Here we generated a Brca1CC mouse with a coiled-coil (CC) domain deletion. Brca1CC/CC mice are born at low...
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