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Article

BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids.

Nature communications - 1 Jan 2013

Chandramouly Gurushankar, Kwok Amy, Huang Bin, Willis Nicholas A, Xie Anyong, Scully Ralph

Abstract excerpt

BRCA1 controls early steps of the synthesis-dependent strand annealing (SDSA) pathway of homologous recombination, but has no known role following Rad51-mediated synapsis. Here we show that BRCA1 influences post-synaptic homologous recombination events, controlling the balance between short- (STGC) and long-tract gene conversion (LTGC) between sister chromatids. Brca1 mutant cells reveal a bias towards LTGC that...

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Share to BRCA1 Protein
Share to Chromatids
Share to Crossing Over, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to Endodeoxyribonucleases

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Share to Genes, Reporter

Share to RNA, Small Interfering

Source

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Identifiers

PMID: 23994874
DOI: 10.1038/ncomms3404
PMCID: PMC3838905

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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