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Article

Off-Target Deletion of Conditional Dbc1 Allele in the Foxp3YFP-Cre Mouse Line under Specific Setting.

Cells - 24 Oct 2019

Xie Chichu, Zhu Fangming, Wang Julie, Zhang Weizhou, Bellanti Joseph A, Li Bin, Brand David, Olsen Nancy, Zheng Song Guo

Abstract excerpt

The Cre-LoxP conditional knockout strategy has been used extensively to study gene function in a specific cell-type. In this study, the authors tried to engineer mice in which the Dbc1 gene is conditionally knocked out in Treg cells. Unexpectedly, the conditional Dbc1 allele was completely deleted with a low frequency in some Foxp3YFP-Cre mice harboring floxed Dbc1 allele under specific settings. It was found...

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Identifiers

PMID: 31652947
DOI: 10.3390/cells8111309
PMCID: PMC6912351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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