Article

A pancreas specific <i>Ptf1a</i> -driven Cre mouse line causes paternally transmitted germline recombination

2020-03-14

Abstract excerpt

Cre- lox P recombination system is a commonly used tool to achieve site-specific genetic manipulation in genome. For multiple Cre driver mouse lines, parental transmissions of recombined flox alleles are reported. Ptf1a -driven Cre lines are widely used to achieve genetic manipulation in a pancreas specific manner. Herein, we report germline recombination in breedings when Cre allele is retained paternally in...

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Literature Corpus work: 275fc5f9-ee29-5a74-8c9b-dc273baed6ae
DOI: 10.1101/2020.03.13.989178

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