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Article

Ectopic germline recombination activity of the widely used Foxp3-YFP-Cre mouse: a case report.

Immunology - 1 Feb 2020

Wu Dan, Huang Qing, Orban Paul C, Levings Megan K

Abstract excerpt

Regulatory T (Treg) cell-specific deletion of a gene of interest is a procedure widely used to study mechanisms controlling Treg development, homeostasis and function. Accordingly, several transgenic mouse lines have been generated that bear the Cre recombinase under control of the Foxp3 promoter either as a random transgene insertion or knocked into the endogenous Foxp3 locus, with the Foxp3YFP-Cre strain of...

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PMID: 31713233
DOI: 10.1111/imm.13153
PMCID: PMC6954732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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