Targeting Gene Function in Germinal Center B Cells: A Practical Approach.

doi:10.1007/978-1-4939-7095-7_17

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Article

Targeting Gene Function in Germinal Center B Cells: A Practical Approach.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Petrocelli Valentina, Casola Stefano

Abstract excerpt

The germinal center (GC) reaction represents an essential phase of an adaptive immune response. Dysfunction of GC B cells can lead to life-threatening diseases including autoimmune disorders, lymphomas, and opportunistic infections. Defining the molecular circuitries controlling GC B cell physiology is crucial to understand the pathogenesis of GC B cell disorders, as well as to develop improved vaccines against...

Topics

Adaptive Immunity
Alleles
Animals
Apoptosis
B-Lymphocytes
Cell Line
Chromatin Immunoprecipitation
Epigenesis, Genetic
Female
Flow Cytometry
Gene Targeting
Genetic Association Studies
Genetic Predisposition to Disease
Genome-Wide Association Study
Germinal Center
Histones
Homologous Recombination
Immunization

Source

Open in PubMed

Identifiers

PMID: 28589359
DOI: 10.1007/978-1-4939-7095-7_17

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