Article
Targeting Gene Function in Germinal Center B Cells: A Practical Approach.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Petrocelli Valentina, Casola Stefano
Abstract excerpt
The germinal center (GC) reaction represents an essential phase of an adaptive immune response. Dysfunction of GC B cells can lead to life-threatening diseases including autoimmune disorders, lymphomas, and opportunistic infections. Defining the molecular circuitries controlling GC B cell physiology is crucial to understand the pathogenesis of GC B cell disorders, as well as to develop improved vaccines against...
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