Article
Phenotypic Diversity Caused by Differential Expression of SFTPC-Cre-Transgenic Alleles.
American journal of respiratory cell and molecular biology - 1 Jun 2020
Jiang Mao, Roth Mark G, Chun-On Pattra, Sullivan Daniel I, Alder Jonathan K
Abstract excerpt
Type II alveolar epithelial cells (AEC2s) play an essential role in the function and maintenance of the pulmonary epithelium. Several transgenic mice have been developed to study the function of these cells in vivo by using the human SFTPC promoter to drive expression of Cre recombinase. The precise activity of each of these transgenic alleles has not been studied, and previous reports suggest that their activity...
Topics
- Alleles
- Alveolar Epithelial Cells
- Animals
- Cell Lineage
- Cellular Senescence
- Female
- Gene Expression Regulation, Developmental
- Genes, Lethal
- Genes, Reporter
- Genetic Association Studies
- Humans
- Integrases
- Lung
- Male