The evolutionary landscape of colorectal tumorigenesis.

doi:10.1038/s41559-018-0642-z

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The evolutionary landscape of colorectal tumorigenesis.

Nature ecology & evolution - 1 Oct 2018

Cross William, Kovac Michal, Mustonen Ville, Temko Daniel, Davis Hayley, Baker Ann-Marie, Biswas Sujata, Arnold Roland, Chegwidden Laura, Gatenbee Chandler, Anderson Alexander R, Koelzer Viktor H, Martinez Pierre, Jiang Xiaowei, Domingo Enric, Woodcock Dan J, Feng Yun, Kovacova Monika, Maughan Tim, Jansen Marnix, Rodriguez-Justo Manuel, Ashraf Shazad, Guy Richard, Cunningham Christopher, East James E, Wedge David C, Wang Lai Mun, Palles Claire, Heinimann Karl, Sottoriva Andrea, Leedham Simon J, Graham Trevor A, Tomlinson Ian P M

Abstract excerpt

The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, we investigate the evolutionary fitness landscape occupied by these neoplasms. Unlike carcinomas, advanced adenomas frequently harbour sub-clonal driver mutations-considered to be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinogenesis

Share to Carcinoma

Share to Colorectal Neoplasms

Share to Evolution, Molecular

Share to Genetic factors in colorectal cancer

Share to Models, Biological

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 30177804
DOI: 10.1038/s41559-018-0642-z
PMCID: PMC6152905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The evolutionary landscape of colorectal tumorigenesis.PMID 30177804Read ↗

The Evolutionary Landscape of Colorectal Tumorigenesis: Recent Paradigms, Models, and Hypotheses.Semantic proximity Read ↗

The landscape of somatic mutation in normal colorectal epithelial cells.Semantic proximity Read ↗

Tumour heterogeneity and evolutionary dynamics in colorectal cancerSemantic proximity Read ↗

The landscape of somatic mutation in normal colorectal epithelial cellsSemantic proximity Read ↗

New insights into the earliest stages of colorectal tumorigenesis.Semantic proximity Read ↗

The somatic mutation landscape of premalignant colorectal adenoma.Semantic proximity Read ↗

An enhanced genetic model of colorectal cancer progression historySemantic proximity Read ↗

Clonal origins and parallel evolution of regionally synchronous colorectal adenoma and carcinoma.Semantic proximity Read ↗

Evolutionary history of human colitis-associated colorectal cancer.Semantic proximity Read ↗

Subclonal diversity arises early even in small colorectal tumours and contributes to differential growth fates.Semantic proximity Read ↗

Clonal evolution of colorectal cancer in IBD.Semantic proximity Read ↗

A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.