Article
Runx transcription factors in the development and function of the definitive hematopoietic system.
Blood - 13 Apr 2017
de Bruijn Marella, Dzierzak Elaine
Abstract excerpt
The Runx family of transcription factors (Runx1, Runx2, and Runx3) are highly conserved and encode proteins involved in a variety of cell lineages, including blood and blood-related cell lineages, during developmental and adult stages of life. They perform activation and repressive functions in the regulation of gene expression. The requirement for Runx1 in the normal hematopoietic development and its...
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