Platelet‑derived growth factor‑BB promotes proliferation and migration of retinal microvascular pericytes by up‑regulating the expression of C‑X‑C chemokine receptor types 4

Abstract excerpt

Stromal cell-derived growth factor (SDF)-1α acts as a ligand to C-X-C chemokine receptors 4 (CXCR4) and 7 (CXCR7), which are involved in the formation of choroidal neovascularization. Previous studies have demonstrated crosstalk between the platelet-derived growth factor (PDGF)-BB/PDGF receptor (PDGFR)-β and SDF-1α/CXCR4 axes during tumor neovascularization by increasing the recruitment of pericytes. However, the...

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