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Article

PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors.

The Journal of cell biology - 1 May 1994

Battegay E J, Rupp J, Iruela-Arispe L, Sage E H, Pech M

Abstract excerpt

To delineate potential angiogenic roles of platelet-derived growth factor (PDGF), we have investigated PDGF and its receptors on bovine aortic endothelial cells that exhibit spontaneous angiogenesis in vitro (angiogenic endothelial cells). Initiation of cord/tube formation by angiogenic endothelial cells required bovine or human serum. Neutralization of PDGF-BB in human serum with a monoclonal anti-PDGF-BB...

Topics

Animals
Becaplermin
Cattle
Cell Division
Cells, Cultured
Culture Media
Culture Media, Serum-Free
DNA
Endothelium, Vascular
Humans
Neovascularization, Pathologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Platelet-Derived Growth Factor

Proto-Oncogene Proteins c-sis

Receptors, Platelet-Derived Growth Factor

Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7514607
DOI: 10.1083/jcb.125.4.917
PMCID: PMC2120083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7514607-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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