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Article

miR-34c inhibits PDGF-BB-induced HAVSMCs phenotypic transformation and proliferation via PDGFR-β/SIRT1 pathway.

Molecular biology reports - 1 May 2021

Wan Wei-Feng, Zhang Xin, Huang Chang-Ren, Chen Li-Gang, Yang Xiao-Bo, Bao Kun-Yang, Peng Tang-Ming

Abstract excerpt

The purpose of this study was to explore the effect of miR-34c on PDGF-BB-induced HAVSMCs phenotypic transformation and proliferation via PDGFR-β/SIRT1 pathway, so as to find a new method for early diagnosis and treatment of cardiovascular disease. HA-VSMCs were treated with platelet-derived growth factor-BB (PDGF-BB) at 0 h, 12 h, 24 h, 48 h or 36 h to explore the optimal time for phenotypic transformation of...

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Source

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Identifiers

PMID: 34110576
DOI: 10.1007/s11033-021-06427-5
PMCID: PMC8260521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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