Article
In vivo angiogenic phenotype of endothelial cells and pericytes induced by vascular endothelial growth factor-A.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Jan 2004
Witmer Antonella N, van Blijswijk Bart C, van Noorden Cornelis J F, Vrensen Gijs F J M, Schlingemann Reinier O
Abstract excerpt
VEGF-A is a major angiogenesis and permeability factor. Its cellular effects, which can be used as targets in anti-angiogenesis therapy, have mainly been studied in vitro using endothelial cell cultures. The purpose of the present study was to further characterize these effects in vivo in vascular endothelial cells and pericytes, in an experimental monkey model of VEGF-A-induced iris neovascularization. Two...
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