Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aberrant proliferation in CXCR7+ endothelial cells via degradation of the retinoblastoma protein.

PloS one - 1 Jan 2013

Totonchy Jennifer E, Osborn Jessica M, Botto Sara, Clepper Lisa, Moses Ashlee V

Abstract excerpt

Angiogenesis is a critical factor in the growth and dissemination of solid tumors. Indeed, tumor vasculature is abnormal and contributes to the development and spread of malignancies by creating a hostile microenvironment. The alternative SDF-1/CXCL12 receptor, CXCR7, is frequently and specifical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Endothelial Cells
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Neovascularization, Pathologic

Share to Proteasome Endopeptidase Complex

Share to Protein Array Analysis

Share to Retinoblastoma Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 23894550
DOI: 10.1371/journal.pone.0069828
PMCID: PMC3720914

Genes

CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23894550-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aberrant proliferation in CXCR7+ endothelial cells via degradation of the retinoblastoma protein.PMID 23894550Read ↗

Expression and Functional Heterogeneity of Chemokine Receptors CXCR4 and CXCR7 in Primary Patient-Derived Glioblastoma CellsSemantic proximity Read ↗

Involvement of the CXCR7/CXCR4/CXCL12 Axis in the Malignant Progression of Human NeuroblastomaSemantic proximity Read ↗

CXCR4 expression heterogeneity in neuroblastoma cells due to ligand-independent regulationSemantic proximity Read ↗

At the Bench: Pre-clinical evidence for multiple functions of CXCR4 in cancer.Semantic proximity Read ↗

CXCR1 and CXCR2 silencing modulates CXCL8-dependent endothelial cell proliferation, migration and capillary-like structure formation.Semantic proximity Read ↗

CXCR4 intracellular protein regulates drug resistance and tumorigenic potential via modulating the expression of Death Receptor 5Semantic proximity Read ↗

CXCR7 stimulates MAPK signaling to regulate hepatocellular carcinoma progression.Semantic proximity Read ↗

Tyrosine phosphorylation of DEP-1/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion, and capillary formation.Semantic proximity Read ↗

Platelet‑derived growth factor‑BB promotes proliferation and migration of retinal microvascular pericytes by up‑regulating the expression of C‑X‑C chemokine receptor types 4Semantic proximity Read ↗

β-Arrestin-2 Counters CXCR7-Mediated EGFR Transactivation and Proliferation.Semantic proximity Read ↗

CXCR2 Inhibition Combined with Sorafenib Improved Antitumor and Antiangiogenic Response in Preclinical Models of Ovarian Cancer.Semantic proximity Read ↗

Eph Receptors and Ephrins: Therapeutic OpportunitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.