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Article

Aberrant proliferation in CXCR7+ endothelial cells via degradation of the retinoblastoma protein.

PloS one - 1 Jan 2013

Totonchy Jennifer E, Osborn Jessica M, Botto Sara, Clepper Lisa, Moses Ashlee V

Abstract excerpt

Angiogenesis is a critical factor in the growth and dissemination of solid tumors. Indeed, tumor vasculature is abnormal and contributes to the development and spread of malignancies by creating a hostile microenvironment. The alternative SDF-1/CXCL12 receptor, CXCR7, is frequently and specifically expressed in tumor-associated vessels. In this study, we examine the role of endothelium-expressed CXCR7 in tumor...

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Share to Cell Proliferation
Share to Endothelial Cells
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Neovascularization, Pathologic

Share to Proteasome Endopeptidase Complex

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Share to Retinoblastoma Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 23894550
DOI: 10.1371/journal.pone.0069828
PMCID: PMC3720914

Genes

CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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