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Article

APOE genotype affects metabolic and Alzheimer‐related outcomes induced by Western diet in female EFAD mice

3 Dec 2018

Abstract excerpt

Development of Alzheimer's disease (AD) is regulated by interactive effects of genetic and environmental risk factors. The most significant genetic risk factor for AD is the ε4 allele of apolipoprotein E ( APOE4), which has been shown to exert greater AD risk in women. An important modifiable AD risk factor is obesity and its associated metabolic dysfunctions. Whether APOE genotype might interact with obesity in...

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PMID: 30509127
DOI: 10.1096/fj.201801756r

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