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Article

HIF-transcribed p53 chaperones HIF-1α

4 Sept 2019

Abstract excerpt

Chronic hypoxia is associated with a variety of physiological conditions such as rheumatoid arthritis, ischemia/reperfusion injury, stroke, diabetic vasculopathy, epilepsy and cancer. At the molecular level, hypoxia manifests its effects via activation of HIF-dependent transcription. On the other hand, an important transcription factor p53, which controls a myriad of biological functions, is rendered...

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PMID: 31538203
DOI: 10.1093/nar/gkz766

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