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Article

Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge.

Cancer science - 1 Mar 2018

Koyasu Sho, Kobayashi Minoru, Goto Yoko, Hiraoka Masahiro, Harada Hiroshi

Abstract excerpt

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator of various genes related to cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF-1 activity have been implicated in the pathogenesis of various diseases including malignant tumors and, thus, elucidating the molecular mechanisms underlying the activation of HIF-1 is eagerly desired for the development of novel...

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Identifiers

PMID: 29285833
DOI: 10.1111/cas.13483
PMCID: PMC5834787

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