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Article

Cellular adaptation to hypoxia and p53 transcription regulation

1 May 2009

Abstract excerpt

Tumor suppressor p53 is the most frequently mutated gene in human tumors. Meanwhile, under stress conditions, p53 also acts as a transcription factor, regulating the expression of a series of target genes to maintain the integrity of genome. The target genes of p53 can be classified into genes regulating cell cycle arrest, genes involved in apoptosis, and genes inhibiting angiogenesis. p53 protein contains a...

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PMID: 19434769
DOI: 10.1631/jzus.b0820293

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