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Article

Chaperoning of mutant p53 protein by wild-type p53 protein causes hypoxic tumor regression.

The Journal of biological chemistry - 20 Jan 2012

Gogna Rajan, Madan Esha, Kuppusamy Periannan, Pati Uttam

Abstract excerpt

Mutant (Mt) p53 abrogates tumor suppression functions of wild-type (WT) p53 through mutant-specific, gain-of-function effects, and patients bearing Mt p53 are chemoresistant. The dominant negative effect of p53 mutants results from their aggregation propensity which causes co-aggregation of WT p5...

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Identifiers

PMID: 22147694
DOI: 10.1074/jbc.M111.317354
PMCID: PMC3268447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22147694-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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