Chaperoning of mutant p53 protein by wild-type p53 protein causes hypoxic tumor regression.

Abstract excerpt

Mutant (Mt) p53 abrogates tumor suppression functions of wild-type (WT) p53 through mutant-specific, gain-of-function effects, and patients bearing Mt p53 are chemoresistant. The dominant negative effect of p53 mutants results from their aggregation propensity which causes co-aggregation of WT p53. We explored the mechanism of p53 inactivation in hypoxia and hypothesized whether WT p53 could rescue Mt p53 in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Hypoxia
• Share to Hep G2 Cells
• Share to Mice