Article

Identification and characterisation of the post-translational modifications that regulate the Hypoxia Inducible Factors, HIF-1α and HIF-2α

2020-01-01

Abstract excerpt

Eukaryotic organisms, including human, require molecular oxygen (O2) to survive. During periods of low O2 availability (hypoxia), a family of protein transcription factors become stabilised (Hypoxia Inducible Factors, HIF) and allow the adaption to hypoxia by regulating gene expression. Hypoxic adaption is required for cellular survival and is considered a hallmark of cancer. HIF is a heterodimeric protein consist...

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Literature Corpus work: 57c2a2b5-3677-5963-a6da-133aa6353596
DOI: 10.17638/03071020

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