Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia signaling in human diseases and therapeutic targets

1 Jun 2019

Abstract excerpt

Since the discovery of hypoxia-inducible factor (HIF), numerous studies on the hypoxia signaling pathway have been performed. The role of HIF stabilization during hypoxia has been extended from the induction of a single gene erythropoietin to the upregulation of a couple of hundred downstream targets, which demonstrates the complexity and importance of the HIF signaling pathway. Accordingly, HIF and its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Metabolism, Diabetes, and Cancer
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31221962
DOI: 10.1038/s12276-019-0235-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia signaling in human diseases and therapeutic targetsPMID 31221962Read ↗

Hypoxia signaling in human health and diseases: implications and prospects for therapeuticsSemantic proximity Read ↗

Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancerSemantic proximity Read ↗

Expression of hypoxia-inducible factor 1: mechanisms and consequencesSemantic proximity Read ↗

HIF in Kidney Disease and DevelopmentSemantic proximity Read ↗

Hypoxia-Inducible Factor 1: Control of Oxygen Homeostasis in Health and DiseaseSemantic proximity Read ↗

Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and Its Implication for MedicineSemantic proximity Read ↗

Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools.Semantic proximity Read ↗

HIF-1: mediator of physiological and pathophysiological responses to hypoxiaSemantic proximity Read ↗

Hypoxia, HIF, and Associated Signaling Networks in Chronic Kidney DiseaseSemantic proximity Read ↗

Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and RepairSemantic proximity Read ↗

Hypoxia: Overview on Hypoxia-Mediated Mechanisms with a Focus on the Role of HIF GenesSemantic proximity Read ↗

Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.