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Article

Interaction of Genetic Variations in NFE2L2 and SELENOS Modulates the Risk of Hashimoto's Thyroiditis

20 Aug 2019

Abstract excerpt

Background: Several single-nucleotide polymorphisms (SNPs) are known to increase the risk of Hashimoto's thyroiditis (HT); such SNPs reside in thyroid-specific genes or in genes related to autoimmunity, inflammation, and/or cellular defense to stress. The transcription factor Nrf2, encoded by NFE2L2 , is a master regulator of the cellular antioxidant response. This study aimed to evaluate the impact of genetic...

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PMID: 31426718
DOI: 10.1089/thy.2018.0480

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