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Article

Polymorphisms in thioredoxin reductase and selenoprotein K genes and selenium status modulate risk of prostate cancer.

PloS one - 1 Jan 2012

Méplan Catherine, Rohrmann Sabine, Steinbrecher Astrid, Schomburg Lutz, Jansen Eugène, Linseisen Jakob, Hesketh John

Abstract excerpt

Increased dietary intake of Selenium (Se) has been suggested to lower prostate cancer mortality, but supplementation trials have produced conflicting results. Se is incorporated into 25 selenoproteins. The aim of this work was to assess whether risk of prostate cancer is affected by genetic variants in genes coding for selenoproteins, either alone or in combination with Se status. 248 cases and 492 controls from...

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Source

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Identifiers

PMID: 23133653
DOI: 10.1371/journal.pone.0048709
PMCID: PMC3486803

Genes

TXNRD1
TXNRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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