The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.

doi:10.1371/journal.pgen.1000637

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Article

The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.

PLoS genetics - 1 Sept 2009

Landa Iñigo, Ruiz-Llorente Sergio, Montero-Conde Cristina, Inglada-Pérez Lucía, Schiavi Francesca, Leskelä Susanna, Pita Guillermo, Milne Roger, Maravall Javier, Ramos Ignacio, Andía Víctor, Rodríguez-Poyo Paloma, Jara-Albarrán Antonino, Meoro Amparo, del Peso Cristina, Arribas Luis, Iglesias Pedro, Caballero Javier, Serrano Joaquín, Picó Antonio, Pomares Francisco, Giménez Gabriel, López-Mondéjar Pedro, Castello Roberto, Merante-Boschin Isabella, Pelizzo Maria-Rosa, Mauricio Didac, Opocher Giuseppe, Rodríguez-Antona Cristina, González-Neira Anna, Matías-Guiu Xavier, Santisteban Pilar, Robledo Mercedes

Abstract excerpt

In order to identify genetic factors related to thyroid cancer susceptibility, we adopted a candidate gene approach. We studied tag- and putative functional SNPs in genes involved in thyroid cell differentiation and proliferation, and in genes found to be differentially expressed in thyroid carcinoma. A total of 768 SNPs in 97 genes were genotyped in a Spanish series of 615 cases and 525 controls, the former...

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PMID: 19730683
DOI: 10.1371/journal.pgen.1000637
PMCID: PMC2727793

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FOXE1

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