Article
Investigation of Break-Induced Replication in Yeast.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Osia Beth, Elango Rajula, Kramara Juraj, Roberts Steven A, Malkova Anna
Abstract excerpt
Repair of double-strand DNA breaks (DSBs) is important for preserving genomic integrity and stability. Break-induced replication (BIR) is a mechanism aimed to repair one-ended double-strand DNA breaks, similar to those formed by replication fork collapse or by telomere erosion. Unlike S-phase replication, BIR is carried out by a migrating DNA bubble and is associated with conservative inheritance of newly...
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