Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Partial rescue of insulin receptor-deficient mice by transgenic complementation with an activated insulin receptor in the liver.

Gene - 16 Oct 2002

Baudry Anne, Jackerott Malene, Lamothe Betty, Kozyrev Sergey V, Leroux Loïc, Durel Béatrice, Saint-Just Susan, Joshi Rajiv L

Abstract excerpt

Insulin receptor (IR)-deficient mice develop severe diabetes mellitus, diabetic ketoacidosis (DKA) and liver steatosis and die within 1 week after birth. We examined in this work whether the metabolic phenotype of IR(-/-) mutants could be improved by transgenic complementation with IR selectively in the liver. We first generated transgenic mice expressing a human DNA complementary to RNA encoding a truncated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Tolerance Test

Share to Mice, Inbred CBA

Share to Phenylalanine Hydroxylase

Share to Receptor, Insulin

Share to Survival Analysis

Source

Identifiers

PMID: 12459269
DOI: 10.1016/s0378-1119(02)01075-2

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Partial rescue of insulin receptor-deficient mice by transgenic complementation with an activated insulin receptor in the liver.PMID 12459269Read ↗

Restoration of insulin receptor improves diabetic phenotype in T2DM miceSemantic proximity Read ↗

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity.Semantic proximity Read ↗

Haploinsufficiency in the PPARalpha and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia.Semantic proximity Read ↗

Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes.Semantic proximity Read ↗

The hepatocyte insulin receptor is required to program rhythmic gene expression and the liver clockSemantic proximity Read ↗

Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.Semantic proximity Read ↗

Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform.Semantic proximity Read ↗

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistanceSemantic proximity Read ↗

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy.Semantic proximity Read ↗

The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.Semantic proximity Read ↗

Beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor-1alpha in mice: diabetes model with beta-cell dysfunction partially rescued by nonglucose secretagogues.Semantic proximity Read ↗

Mouse insulin cells expressing an inducible RIPCre transgene are functionally impaired.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.