Article

The hepatocyte insulin receptor is required to program rhythmic gene expression and the liver clock

2021-02-07

Abstract excerpt

<h4>SUMMARY</h4> In mammalian cells, gene expression is rhythmic and sensitive to various environmental and physiological stimuli. A circadian clock system helps to anticipate and synchronize gene expression with daily stimuli including cyclic light and food intake, which control the central and peripheral clock programs, respectively. Food intake also regulates insulin secretion. How much insulin contributes to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f7c5f2f-d8aa-5b38-9ea4-9bc6fc4cb97b
DOI: 10.1101/2021.02.05.430014

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The hepatocyte insulin receptor is required to program rhythmic gene expression and the liver clockDOI 10.1101/2021.02.05.430014Read

Circadian Regulation of Gene Expression and Metabolism in the LiverSemantic proximity Read

Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signalingSemantic proximity Read

p110α-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLDSemantic proximity Read

The liver clock tunes transcriptional rhythms in skeletal muscle to regulate mitochondrial functionSemantic proximity Read

Hepatocyte ERα orchestrates sex-specific liver adaptation to fasting and feeding statesSemantic proximity Read

Circadian Clock and Liver CancerSemantic proximity Read

The regulation of circadian rhythm by insulin signaling in <i>Drosophila</i>Semantic proximity Read

Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform.Semantic proximity Read

Mice with humanized livers reveal the involvement of hepatocyte circadian clocks in rhythmic behavior and physiologySemantic proximity Read

Insulin-induced Gene 2 Protects against Hepatic Ischemia-reperfusion Injury via Metabolic RemodelingSemantic proximity Read

SREBP-1 as a Transcriptional Integrator of Circadian and Nutritional Cues in the LiverSemantic proximity Read

Hepatocyte-specific deletion of <i>Pparα</i> promotes NASH in the context of obesitySemantic proximity Read