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Article

Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.

The Journal of clinical investigation - 1 Oct 2001

Guerra C, Navarro P, Valverde A M, Arribas M, Brüning J, Kozak L P, Kahn C R, Benito M

Abstract excerpt

Although insulin regulates metabolism in both brown and white adipocytes, the role of these tissues in energy storage and utilization is quite different. Recombination technology using the Cre-loxP approach allows inactivation of the insulin receptor in a tissue-specific manner. Mice lacking insulin receptors in brown adipocytes show an age-dependent loss of interscapular brown fat but increased expression of...

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Share to Adipose Tissue, Brown
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Insulin Resistance

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Share to Receptor, Insulin

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Source

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Identifiers

PMID: 11602628
DOI: 10.1172/JCI13103
PMCID: PMC209529

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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