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Article

Role of MYC-miR-29-B7-H3 in Medulloblastoma Growth and Angiogenesis

2 Aug 2019

Abstract excerpt

Medulloblastoma (MB) is the most common embryonal neuroepithelial tumor, with poor patient outcomes and secondary complications. In this study, we investigated the role of the B7 family of immune checkpoint homolog 3 (B7-H3) expression in MB angiogenesis. B7-H3, a co-inhibitory immune checkpoint, is highly expressed and is associated with lower overall survival in MYC+ MB’s. Evidence for a direct transcriptional...

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PMID: 31382461
DOI: 10.3390/jcm8081158

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