High B7-H3 protein expression in Medulloblastoma is associated with metastasis and unfavorable patient outcomes

Abstract excerpt

BACKGROUND: Medulloblastoma (MB) is the most common malignant brain tumor in children. Although the 5-year survival rate is approximately 70-80%, the current standard treatment results in severe and long-term side effects. The search for new anticancer immunotherapeutic targets has identified B7-H3 as a promising candidate in various solid tumors. However, the role of B7-H3 in MB remains unclear, and studies...

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