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Integrative molecular analyses define correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancer

2 Nov 2022

Abstract excerpt

B7-H3 (CD276) is an immune checkpoint overexpressed in prostate cancer with minimal expression in normal tissues and associated with poor prognosis, making it an excellent therapy target. We interrogated B7-H3 expression and its regulation in metastatic castration-resistant prostate cancer (mCRPC). We found greater expression of B7-H3 transcript relative to other immunotherapy targets (CTLA-4, PD-L1/2), including...

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PMID: 36323882
DOI: 10.1038/s41698-022-00323-2

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