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Article

The non-cell-autonomous component of ALS: new in vitro models and future challenges.

Biochemical Society transactions - 1 Oct 2014

Ferraiuolo Laura

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting the motor nerves. At present, there is no effective therapy for this devastating disease and only one Food and Drug Administration (FDA)-approved drug, riluzole, is known to moderately extend survival. In the last decade, the field of ALS has made a remarkable leap forward in understanding some of the genetic causes of this...

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PMID: 25233402
DOI: 10.1042/BST20140168

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