Article
Gene loci associated with insulin secretion in islets from non-diabetic mice.
The Journal of clinical investigation - 25 Jul 2019
Keller Mark P, Rabaglia Mary E, Schueler Kathryn L, Stapleton Donnie S, Gatti Daniel M, Vincent Matthew, Mitok Kelly A, Wang Ziyue, Ishimura Takanao, Simonett Shane P, Emfinger Christopher H, Das Rahul, Beck Tim, Kendziorski Christina, Broman Karl W, Yandell Brian S, Churchill Gary A, Attie Alan D
Abstract excerpt
Genetic susceptibility to type 2 diabetes is primarily due to β-cell dysfunction. However, a genetic study to directly interrogate β-cell function ex vivo has never been previously performed. We isolated 233,447 islets from 483 Diversity Outbred (DO) mice maintained on a Western-style diet, and measured insulin secretion in response to a variety of secretagogues. Insulin secretion from DO islets ranged...
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