Article
Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology.
Nature metabolism - 1 Oct 2024
Madsen A L, Bonàs-Guarch S, Gheibi S, Prasad R, Vangipurapu J, Ahuja V, Cataldo L R, Dwivedi O, Hatem G, Atla G, Guindo-Martínez M, Jørgensen A M, Jonsson A E, Miguel-Escalada I, Hassan S, Linneberg A, Ahluwalia Tarunveer S, Drivsholm T, Pedersen O, Sørensen T I A, Astrup A, Witte D, Damm P, Clausen T D, Mathiesen E, Pers T H, Loos R J F, Hakaste L, Fex M, Grarup N, Tuomi T, Laakso M, Mulder H, Ferrer J, Hansen T
Abstract excerpt
The genetics of β-cell function (BCF) offer valuable insights into the aetiology of type 2 diabetes (T2D)1,2. Previous studies have expanded the catalogue of BCF genetic associations through candidate gene studies3-7, large-scale genome-wide association studies (GWAS) of fasting BCF8,9 or functional islet studies on T2D risk variants10-14. Nonetheless, GWAS focused on BCF traits derived from oral glucose...
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