Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovering human diabetes-risk gene function with genetics and physiological assays

17 Sept 2018

Abstract excerpt

Developing systems to identify the cell type-specific functions regulated by genes linked to type 2 diabetes (T2D) risk could transform our understanding of the genetic basis of this disease. However, in vivo systems for efficiently discovering T2D risk gene functions relevant to human cells are currently lacking. Here we describe powerful interdisciplinary approaches combining Drosophila genetics and physiology...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetics, Aging, and Longevity in Model Organisms
Share to Genetics and Neurodevelopmental Disorders
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30242153
DOI: 10.1038/s41467-018-06249-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovering human diabetes-risk gene function with genetics and physiological assaysPMID 30242153Read ↗

Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics.Semantic proximity Read ↗

Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic isletsSemantic proximity Read ↗

From Genetic Association to Molecular Mechanisms for Islet-cell Dysfunction in Type 2 Diabetes.Semantic proximity Read ↗

Single-cell decoding of human islet cell type-specific alterations in type 2 diabetes reveals converging genetic- and state-driven β-cell gene expression defectsSemantic proximity Read ↗

A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.Semantic proximity Read ↗

From Biology to Genes and Back Again: Gene Discovery for Monogenic Forms of Beta-Cell Dysfunction in DiabetesSemantic proximity Read ↗

Xenopus as a model system for studying pancreatic development and diabetes.Semantic proximity Read ↗

Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetesSemantic proximity Read ↗

Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells.Semantic proximity Read ↗

The Genetics of Diabetes: What We Can Learn from Drosophila.Semantic proximity Read ↗

Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants.Semantic proximity Read ↗

Untangling the genetics of beta cell dysfunction and death in type 1 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.